Home team listed first. Pairings include seed and record.
All kickoffs at 7:00 PM unless otherwise noted.
Division I – Games at 7 p.m., Friday, Nov. 22
Region 1
1 Mentor (12-0) vs. 2 Lakewood St. Edward (11-1) at Parma Byers Field at Robert M. Boulton Stadium
Region 2
1 Springfield (11-1) vs. 3 Dublin Coffman (10-2) at London Bowlus Field
Region 3
4 Groveport-Madison (10-2) vs. 2 Pickerington Central (11-1) at Columbus St. Francis DeSales Alumni Stadium
Region 4
4 Cincinnati Elder (10-2) vs. 3 Cincinnati Colerain (11-1) at Mason Dwire Field at Atrium Stadium
Division II – Games at 7 p.m., Friday, Nov. 22
Region 5
1 Massillon Washington (12-0) vs. 3 Akron Archbishop Hoban (11-1) at the University of Akron InfoCision Stadium-Summa Field
Region 6
1 Avon (12-0) vs. 2 Avon Lake (11-1) at North Ridgeville Ranger Stadium
Region 7
1 Toledo Central Catholic (12-0) vs. 6 Lewis Center Olentangy (7-5) at Tiffin Columbian Frost-Kalnow Stadium
Region 8
1 Cincinnati La Salle (10-2) vs. 3 Harrison (11-1) at West Chester Lakota West Firebird Stadium
Division III – Games at 7 p.m., Friday, Nov. 22
Region 9
4 Aurora (12-0) vs. 6 Chardon (10-2) at Solon Stewart Field
Region 10
5 Sandusky (9-3) vs. 2 Mansfield Senior (11-1) at Clyde Stadium
Region 11
1 Columbus Bishop Hartley (11-1) vs. 2 Plain City Jonathan Alder (12-0) at Hilliard Darby Stadium
Region 12
4 Hamilton Badin (9-3) vs. 7 Trotwood-Madison (9-3) at Miamisburg Holland Field
Division IV – Games at 7 p.m., Saturday, Nov. 23
Region 13
1 Perry (12-0) vs. 2 Poland Seminary (10-2) at Austintown-Fitch Greenwood Chevrolet Falcon Stadium
Region 14
8 Clyde (8-4) vs. 6 Ottawa-Glandorf (9-3) at Findlay Donnell Stadium
Region 15
1 Newark Licking Valley (12-0) vs. 7 Carroll Bloom-Carroll (10-2) at Columbus St. Francis DeSales Alumni Stadium
Region 16
1 Cincinnati Wyoming (12-0) vs. 7 Germantown Valley View (10-2) at Cincinnati Princeton Mancuso Viking Stadium
Division V – Games at 7 p.m., Saturday, Nov. 23
Region 17
1 Kirtland (12-0) vs. 2 Akron Manchester (9-3) at Bedford Bearcat Stadium
Region 18
1 Oak Harbor (12-0) vs. 2 Orrville (11-1) at Elyria Mercy Field at Ely Stadium
Region 19
1 Ironton (11-1) vs. 2 West Lafayette Ridgewood (12-0) at Nelsonville-York Boston Field
Region 20
4 West Liberty-Salem (11-1) vs. 2 West Jefferson (11-1) at Sidney Memorial Stadium
Division VI – Games at 7 p.m., Friday, Nov. 22
Region 21
1 New Middletown Springfield (12-0) vs. 2 Mogadore (11-1) at Canfield South Range Ralph and Doris Witmer Field
Region 22
8 Carey (7-5) vs. 3 Howard East Knox (12-0) at Marion Harding Ohio Health Field at Harding Stadium
Region 23
5 Anna (11-1) vs. 3 Archbold (11-1) at Lima Senior Spartan Stadium
Region 24
4 Covington (10-2) vs. 6 Mechanicsburg (10-2) at Piqua Alexander Stadium
Division VII – Games at 7 p.m., Saturday, Nov. 23
Region 25
1 Cuyahoga Heights (10-1) vs. 2 Lucas (10-2) at Canal Fulton Northwest Don Schalmo Field at Dr. Martin Smilek Stadium
Region 26
1 Leipsic (11-1) vs. 3 Hamler Patrick Henry (9-3) at Defiance Fred Brown Athletic Complex
Region 27
1 Canal Winchester Harvest Prep (11-1) vs. 2 Newark Catholic (9-3) at Westerville Central Warhawk Field
Region 28
8 New Bremen (9-3) vs. 2 Maria Stein Marion Local (10-2) at Wapakoneta Harmon Field
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